Selected Publications

Chamilos G, Lewis RE, Hu J, Xiao L, Zal T, Gilliet M, Halder G, Kontoyiannis DP. Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis. Proceedings of National Academy of Sciences, USA, 2008; 105:9367-9372.

Chamilos G, Lionakis MS, Lewis RE, Lopez-Ribot JL, Saville SP, Albert ND, Halder G, Kontoyiannis DP. Drosophila melanogaster as a facile model for large-scale studies of virulence mechanisms and antifungal drug efficacy in Candida. J Infect Dis, 2006, 193:1014-1022

Chamilos G, Nobile CJ, Bruno MV, Lewis RE, Mitchell AP, Kontoyiannis DP. C. albicans cell wall integrity regulator Cas5 promotes virulence in murine and Toll-mutant fly models. J Infect Dis; 2009; 200:152-157.

Ganguly D, Chamilos G, Lande R, Gregorio J, Meller S, Facchinetti V, Homey B, Barrat F, Zal T, Gilliet M. Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and 8. J Exp Med 2009; 206: 1983-1994.

Chamilos G, Ganguly D, Lande R, Gregorio J, Meller S, Goldman GE, Gilliet M, Kontoyiannis DP. b-glucan cell wall exposure induces IL-23-producing DCs and drives TH17 responses to airborne opportunistic fungi. PLoS One 2010; 5:e12955.

Lande R, Ganguly D, Facchinetti V, Gregorio J, Frasca L, Conrad C, Chamilos G, Sebasigari R, Riccieri V, Bassett R, Amuro H, Fukuhara S, Liu YJ, Ito T, Gilliet M. Neutrophils release DNA- antimicrobial peptide complexes that activate pDC and trigger autoimmunity in SLE. Sci Trans Med 2011; 3:73ra19

Chamilos G, Gregorio J, Meller S, Lande R, Kontoyiannis DP, Modlin RL, Gilliet M. Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37. Blood 2012; 120:3699-707

Smeekens SP, Conway KL, Gresnigt MS, Begun J, Plantinga TS, Joosten LAB,. van der Meer JWM, Chamilos G, Netea MG, Xavier RJ, van de Veerdonk FL. Defective autophagy underlies inflammation in chronic granulomatous disease. Proceedings of National Academy of Sciences, USA, 2014; 111:3526-31

Kyrmizi I, Gresnigt MS, Akoumianaki T, Samonis G, Sidiropoulos P, Boumpas D, Netea MG, van de Veerdonk FL, Kontoyiannis DP, Chamilos G*,# . Corticosteroids Block Autophagy Protein Recruitment in Aspergillus fumigatus Phagosomes via Targeting Dectin-1/Syk Kinase Signaling. J Immunol. 2013; 191:1287-99

Lande R†, Georgios Chamilos†, Dipyaman Ganguly†, De Maria O, Frasca L, Conrad C, Schröder J, Gilliet M.. Cationic antimicrobial peptides in psoriatic skin cooperate to break innate tolerance to self-DNA. Eur J Immunol; 2015; 45, 203-213

Frasca L, Lande R, Botti E, Jandus C, Dojcinovic D, Fanelli G, Conrad C, Chamilos G, Feldmeyer L, Marinari B, Chon S, Vence L, Riccieri V, Guillaume P, Navarini A, Romero P, Costanzo A, Piccolella E, Gilliet M. The antimicrobial peptide LL37 is a T cell autoantigen in psoriasis. Nat Commun. 2014, 5:5621

Meller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, Ganguly D, Conrad C, Gregorio J, Le Roy D, Roger T, Ladbury JE, Homey B, Watowich S, Modlin RL, Kontoyiannis DP, Liu YJ, Arold ST, Gilliet M. T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26. Nat Immunol. 2015 Sep;16(9):970-9

Akoumianaki T, Kyrmizi I, Valsecchi I, Gresnigt MS, Samonis G, Drakos E, Boumpas D, Muszkieta L, Prevost MC, Kontoyiannis DP, Chavakis T, Netea MG, van de Veerdonk FL, Brakhage AA, El-Benna J, Beauvais A, Latge JP, Chamilos G. Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity. Cell Host Microbe. 2016 Jan 13;19(1):79-90